About Lab
Advancing Pharmacology: Welcome to Our Lab
Step into our lab, where we delve into pioneering research in pharmacokinetics and pharmacodynamics of immunosuppressant drugs for organ transplantation and the repurposing of anticancer medications. Our primary goal is to translate our findings into clinical trials, driving advancements in patient care.
Explore the realm of organ transplantation as we dissect the pharmacokinetic and pharmacodynamic profiles of routine immunosuppressant drugs. Through comprehensive studies, we optimize dosing regimens, predict drug concentrations, and refine treatment strategies to enhance outcomes for transplant recipients.
Simultaneously, our focus extends to repurposing FDA-approved drugs for oncological purposes. Leveraging in vitro and in vivo methodologies, we evaluate efficacy, safety, and synergistic effects to broaden therapeutic options for cancer patients.
Collaborating closely with clinicians and regulatory bodies, we spearhead clinical trials to validate safety and efficacy. By bridging lab discoveries with clinical practice, we aim to optimize dosing regimens and expand the arsenal of treatments for cancer patients.
At the core of our mission lies patient well-being. We strive to tailor treatments for transplant recipients, ensuring optimal therapeutic response. Similarly, our efforts in oncology seek to provide accessible and effective therapies, enhancing survival rates and quality of life.
Driven by a commitment to translational research, we endeavor to bridge scientific discoveries with practical applications. With cutting-edge techniques and instrumentation, we push the boundaries of pharmacology, making a tangible impact on patient lives. Welcome to the forefront of pharmacological innovation at our Translational Pharmacology Lab.
Our Expertise
Harnessing a blend of cutting-edge research and clinical insight, our team at LAB excels in the field of translational pharmacology. With a relentless dedication to bridging the gap between laboratory discoveries and real-world applications, we focus on unraveling the intricate interactions between drugs and biological systems. Our expertise lies in enhancing drug safety, refining dosing strategies, and pioneering personalized therapeutic approaches to elevate patient care standards.
Molecular Techniques
We utilize a wide range of molecular techniques to study drug properties and their effects on biological systems Our lab is equipped with advanced instruments, including
- Liquid Chromatography Mass Spectrometry (LC MS/MS) LC MS/MS enables precise analysis and quantification of drug compounds, metabolites, and biomarkers in complex biological matrices This technique allows us to investigate drug metabolism, pharmacokinetics, and biodistribution
- High Performance Liquid Chromatography ( HPLC is a powerful analytical technique used for separating, identifying, and quantifying drug compounds and their impurities We employ HPLC to assess drug purity, stability, and formulation
- Reverse Transcription Polymerase Chain Reaction (RT PCR) RT PCR enables the amplification and quantification of specific RNA molecules, providing valuable insights into gene expression profiles We leverage this technique to study the impact of drugs on gene regulation and cellular responses
- Cell Culture and In Vitro Assays Our lab maintains a cell culture facility, allowing us to perform a wide array of in vitro experiments These assays help us evaluate drug efficacy, toxicity, and mechanisms of action at the cellular level
Equipments
To facilitate our research endeavours, our lab is equipped with cutting edge instruments, including but not limited to
- Triple quadrupole LC MS/MS systems for highly sensitive and selective quantification of drugs and metabolites
- High resolution mass spectrometers for accurate mass determination and structural elucidation of compounds
- HPLC systems with various detectors, such as UV Vis, fluorescence, and diode array detectors, enabling comprehensive analysis of drug samples
- Real time PCR machines for sensitive and quantitative gene expression analysis
- Temperature controlled CO 2 incubators and laminar flow hoods for maintaining optimal cell culture conditions
- Advanced microscopes for cellular imaging and analysis
Working Facilities
Our lab offers a collaborative and stimulating working environment We foster a culture of interdisciplinary collaboration, encouraging researchers from diverse backgrounds to come together and exchange ideas Our facilities include well equipped research stations, data analysis workstations, and dedicated areas for meetings and presentations Furthermore, we prioritize safety in our lab We strictly adhere to stringent biosafety and biosecurity protocols, ensuring the well being of our researchers and the integrity of our experiments.
Lab News
Highlights from our Lab Members
Dr. Smita Pattanaik became the Associate Editor of the journal ‘Trials’ in 2023
Ms. Ritika won the best poster award in the e-poster category at ISOT 2022, Nagpur
Mr. Sumit Dey won the second prize in the poster presentation at SOGOCON-2022, Bangalore
Honoured as an invited Alumni to the panel discussion (virtual mode) in the eighth Global Clinical Scholars Research Training program 2020-21, hosted by the Harvard Medical School Boston, United States of America on 4th Dec 2020
Awarded the Paul Dudley White International Scholar award as recognition for the authors with the highest-ranked abstract from India at the International Stroke Conference of the American Heart Association in Los Angeles, USA on 20th May 2020
Awarded the Best Paper-First Prize of the Indian Journal of Urology for the year 2019 for the paper Indian J Urol. 2019;35:25-33 and a plaque to honour this achievement at the Annual meeting of Urological Society of India USICON 2020 at Kochi
Awarded the Best researcher in the category of Additional Professors in the 7th Annual Institute Research Day, for publishing high-quality research in the Institute Research Appreciation Program on PGIMER Annual Research Day on 5th October 2019
Awarded with a travel grant and invited as a speaker to talk on “TDM in India” in the symposium “TDM is Asia” to the World congress of Therapeutic Drug Monitoring and Clinical Toxicology held at Kyoto, Japan 23rd -27th Sept 2017
Serving on the board of International Editors of the British Journal of Clinical Pharmacology of the British Pharmacological Society for a period of 5 years (August 2016 to July 2021)
Received the ‘Eagle Eye Award’ from the Editors of Goodman and Gillman Pharmacological Basis of Therapeutics in June 2016
Awarded the Fulbright-Nehru Academic and Professional Excellence Fellowship for 2014-2015, under the mentorship of Prof. James C Ritchie, Emory Clinical and Translational Research Laboratory of the Emory University School of Medicine and Emory University. Could be found at (http://www.usief.org.in/INF-2014-15/Academic-and-Professional-Excellence-Scholars/Smita-Pattanaik.html)
Awarded Full Scholarship for the ‘Global Clinical Scholars Research Training program 2013-14’ by the Harvard Medical School Boston, United States of America. Could be found at (http://hms.harvard.edu/departments/global-clinical-scholars-research-training-program/gcsrt-program-scholarships)
Awarded Distinction for the CAPSTONE proposal in the ‘Global Clinical Scholars Research Training program 2013-14’ by the Harvard Medical School Boston, United States of America
Awarded the Best researcher in the category of Assistant Professors in the second Institute foundation day Research Appreciation Program in 2013
Join Us
If
you are passionate about translational pharmacology and wish to contribute to ground breaking research, we welcome collaborations, partnerships, and talented individuals to join our team Together, we can drive innovation and
make a significant impact on drug discovery and development.
Contact us: Lab 4030 Department of Pharmacology, Research B lock B, PGIMER, Chandigarh today to learn more about our research, explore collaboration opportunities, or inquire about joining our team.
Let's
work together to shape the future of pharmacology and improve patient care through innovative science.